Selected publications

  • 1
    Francesconi M, Di Stefano B, Berenguer C, de Andrés-Aguayo L, Plana-Carmona M, Mendez-Lago M, Guillaumet-Adkins A, Rodriguez-Esteban G, Gut M, Gut IG, Heyn H, Lehner B, Graf T  Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming. eLife. 2019 Mar 12;8. 

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  • 2
    Sardina JL, Collombet S, Tian T, Gómez A, Di Stefano B, Berenguer C, Brumbaugh J, StadhoudersR, Segura-Morales C, Gut M, Gut IG, Heath S, Aranda S, Di Croce L, Hochedlinger K, Thieffry D and Graf T. Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate. Cell Stem Cell, 23, 1-15 (2018)

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  • 3
    Stadhouders R, Vidal E, Serra F, Di Stefano B, Le Dily F, Quilez J, Gomez A, Collombet S, Berenguer C, Cuartero Y, Hecht J, Filion GJ, Beato M, Marti-Renom MA, Graf T. Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming. Nature Genetics 50(2):238-249 (2018)

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  • 4
    Krijger PHL, Di Stefano B, de Wit E., Limone F, van Oevelen C, de Laat W, and Graf T. Cell-of-origin specific 3D genome structure acquired during somatic cell reprogramming. Cell Stem Cell, 18, 597–610 (2016)

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  • 5
    Di Stefano B, Collombet S, Jakobsen JS, Wierer M, Lacker A, Sardina JL, Segura-Morales C, Stadhouders R, Limone F, Mann M, Porse B, Thievery D, and Graf T.  C/EBPa creates elite cells for iPS cell reprogramming by upregulating Klf4 and post-transcriptionally increasing the levels of Lsd1 and Brd4. Nature Cell Biology, 18(4):371-81 (2016)

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  • 6
    Di Stefano B, Sardina JL, van Oevelen C, Collombet S, Kallin EM, Vicent GP, Lu J, Thieffry D, Beato M, and Graf T. C/EBPa poises B cells for rapid reprogramming into iPS cells. Nature 506, 235-241 (2014)

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  • 7
    Rapino F, Robles EF, Richter-Larrea JA, Kallin EM, Martinez-Climent JA, Graf T. C/EBPα Induces Highly Efficient Macrophage Transdifferentiation of B Lymphoma and Leukemia Cell Lines and Impairs Their Tumorigenicity. Cell Reports 3, 1-11 (2013)

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